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| Physiological Profiling | |
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LOD threshold (Thrd) for Parametric analysis is 2.8 or 2.5 (in a few specific cases). LOD threshold (Thrd) for Non_parametric analysis is 3.5. One phenotype can be mapped on different chromosomes. Group g1 through g18 and phen-group refer to ordering and grouping of phenotypes | ||||||||
| No. | Phen. group | Phen. grp. # | Phen. name | Phen. Description | Chr# | Thrd | LOD Peak | Marker |
| 1 | KID FUNC | g8 | TR_RF_HS_24HR_EXCR_PROTEIN_LN | protein excretion rate, high salt diet | 18 | 2.8 | 2.981 | D18Mgh9 |
| 2 | KID FUNC | g8 | TR_RF_HS_EXCR_PROT_MG24HR_LN | protein excretion rate, high salt diet | 18 | 2.8 | 2.933 | D18Mgh7 |
| 3 | BP | g9 | RAWBP_DAY1_MAP | mean blood pressure, High salt, day 1, mean of 3 hour blood pressure recording | 18 | 3.5 | 3.53873 | D18Rat57 |
| 4 | BP | g9 | RAWBP_DAY2_DAP | Diastolic blood pressure, High salt, day 2, mean of 3 hour blood pressure recording | 18 | 2.8 | 2.829 | D18Rat57 |
| 5 | BP | g9 | RAWBP_DAY2_MAP | mean blood pressure, High salt, day 2, mean of 3 hour blood pressure recording | 18 | 3.5 | 4.41065 | D18Rat57 |
| 6 | BP | g9 | TR_BPX_HSACTIVEDIAMEAN_LN | Diastolic blood pressure, arterial catheter implanted, high salt diet, average of 3 hours collection time, active state - lights off and rat awake | 18 | 2.5 | 2.791 | D18Rat57 |
| 7 | BP | g9 | BPX_HSBASALMAPMEAN | Mean arterial blood pressure, arterial catheter implanted, high salt diet, mean of best 2 out of 3 days, 3 hours collection time per day, basal state - lights on and rat asleep, | 18 | 3.5 | 3.88752 | D18Rat57 |
| 8 | BP | g9 | BPX_HSACTIVEMAPMEAN | Mean arterial pressure, arterial catheter implanted, high salt diet, average of 3 hours collection time, active state - lights off and rat awake | 18 | 3.5 | 4.36484 | D18Rat57 |
| 9 | BP | g9 | DELTA_HS_M_LS_MAPBP | mean arterial pressure, high salt minus low salt, basal state - lights on and rat asleep | 18 | 3.5 | 4.61609 | D18Rat57 |
| 10 | BP | g9 | DELTA_HS_M_LS_SYSBP | Systolic blood pressure, high salt minus low salt, basal state - lights on and rat asleep | 18 | 2.8 | 3.643 | D18Mit3 |
| 11 | BP SD | g10 | RAWBP_DAY2_DAPSD | Diastolic blood pressure standard deviation, High salt, day 2, mean of 3 hour blood pressure recording | 18 | 3.5 | 3.59112 | D18Rat57 |
| 12 | BP SD | g10 | RAWBP_DAY2_MAPSD | mean blood pressure standard deviation, High salt, day 2, mean of 3 hour blood pressure recording | 18 | 3.5 | 3.97196 | D18Rat57 |
| 13 | BP T-SERIES | g11 | BPTSM_TPM_ALPHA2 | Tuesday p.m. Linear term 1st order parameter (mechanistic model) | 18 | 2.8 | 3.807 | D18Mgh3 |
| BP T-SERIES | g11 | BPTSM_TPM_ALPHA2 | Tuesday p.m. Linear term 1st order parameter (mechanistic model) | 18 | 2.8 | 3.201 | D18Mgh9 | |
| 14 | BP T-SERIES | g11 | BPTSM_WAM_ALPHA2 | Wednesday a.m. Linear term 1st order parameter (mechanistic model) | 18 | 2.8 | 3.022 | D18Mgh7 |
| 15 | BP T-SERIES | g11 | BPTSM_WAM_XBAR | Wednesday a.m. Set point for baro-receptor response (mechanistic model) | 18 | 2.8 | 3.053 | D18Rat57 |
| 16 | BP T-SERIES | g11 | TR_BPTSM_TAM_MEAN_LN | Tuesday a.m. mean blood pressure | 18 | 2.8 | 3.269 | D18Rat57 |
| 17 | LIPIDS | g16 | BW_HDL_VALUE | Plasma HDL value, low salt diet following Lasix | 18 | 2.8 | 3.826 | D18Mit8 |
| LIPIDS | g16 | BW_HDL_VALUE | Plasma HDL value, low salt diet following Lasix | 18 | 2.8 | 3.995 | D18Mgh7 | |
| 18 | MORPHO | g17 | ARVA_WGHTCS | Body weight prior to anesthesia for acute protocol | 18 | 2.8 | 2.963 | D18Mit8 |
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BioInformatics Research Center Medical College of Wisconsin Email:zwang@mcw.edu Web:http://brc.mcw.edu/ |