Physiological Profiling
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LOD threshold (Thrd) for Parametric analysis is 2.8 or 2.5 (in a few specific cases). LOD threshold (Thrd) for Non_parametric analysis is 3.5. One phenotype can be mapped on different chromosomes. Group g1 through g18 and phen-group refer to ordering and grouping of phenotypes
No.	Phen. group	Phen. grp. #	Phen. name	Phen. Description	Chr#	Thrd	LOD Peak	Marker
1	BP	g9	DELTA_WAKE_M_DAY2AM_SYSBP	systolic blood pressure, high salt diet, p.m. active state value minus a.m. basal state (mean of 3 hours recording each)	2	3.5	3.66819	D2Mgh29
2	BP SD	g10	TR_RAWBP_DAY3_DAPSD_LN	Diastolic blood pressure standard deviation, High salt, day 3, mean of 3 hour blood pressure recording	2	2.8	3.665	D2Mgh12
3	BP SD	g10	TR_RAWBP_DAY3_MAPSD_LN	mean blood pressure standard deviation, High salt, day 3, mean of 3 hour blood pressure recording	2	2.8	4.377	D2Mgh12
4	BP SD	g10	BPX_HSBASALMAPSD	Mean arterial pressure standard deviation, arterial catheter implanted, high salt diet, mean of best 2 out of 3 days, 3 hours collection time per day, basal state - lights on and rat asleep,	2	3.5	3.61192	D2Mgh12
5	BP T-SERIES	g11	BPTSM_TPM_ALPHA1	Tuesday p.m. Linear term 0th order parameter (mechanistic model)	2	2.8	3.476	D2Mgh1
6	BP T-SERIES	g11	BPTSM_WAM_D	Wednesday a.m. fractal parameter (fARIMA model)	2	3.5	3.62454	D2Mgh26
7	BP DRUG	g12	TR_D_LNAME_M_ACH2_BP_LN	Delta mean arterial pressure from L-NAME minus Acetylcholine dose 2 mean arterial pressure	2	2.8	3.035	D2Mgh15
8	HR	g14	RAWBP_DAY1_HRTRT	heart rate, High salt, day 1, mean of 3 hour blood pressure recording	2	2.8	3.165	D2Rat64
9	HR SD	g15	TR_RAWBP_DAY1_HRTRTSD_LN	heart rate standard deviation, High salt, day 1, mean of 3 hour blood pressure recording	2	2.8	3.373	D2Mit15
10	MORPHO	g17	AP_HEART_WGHT	heart weight in grams	2	3.5	3.50746	D2Mgh12

BioInformatics Research Center Medical College of Wisconsin Email:zwang@mcw.edu Web:http://brc.mcw.edu/