Physiological Profiling
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LOD threshold (Thrd) for Parametric analysis is 2.8 or 2.5 (in a few specific cases). LOD threshold (Thrd) for Non_parametric analysis is 3.5. One phenotype can be mapped on different chromosomes. Group g1 through g18 and phen-group refer to ordering and grouping of phenotypes
No.	Phen. group	Phen. grp. #	Phen. name	Phen. Description	Chr#	Thrd	LOD Peak	Marker
1	RVR ANG	g1	TR_D_ANG3_M_CTRL_RVR_LN	Delta renal vascular resistance from AngII dose 3 minus control renal vascular resistance	5	2.5	2.798	D5Mgh8
2	RVR ACH	g3	DELTA_ACH2_M_CTRL_RVR	Delta renal vascular resistance from Acetylcholine dose 2 minus pre-Ach control renal vascular resistance	5	2.8	4.149	D5Mgh23
3	RBF ACH	g6	DELTA_ACH1_M_CTRL_RBF	Delta renal blood flow from Acetylcholine dose 1 minus pre-Ach control renal blood flow	5	3.5	4.16275	D5Mgh5
4	RBF ACH	g6	DELTA_ACH1_M_CTRL_RBFK	Delta renal blood flow per gram kidney weight from Acetylcholine dose 1 minus pre-Ach control renal blood flow per gram kidney weight	5	3.5	4.36965	D5Mgh5
5	RBF ACH	g6	DELTA_ACH2_M_CTRL_RBF	Delta renal blood flow from Acetylcholine dose 2 minus pre-Ach control renal blood flow	5	2.8	3.296	D5Mit4
6	BP T-SERIES	g11	BPTSM_TPM_ALPHA2	Tuesday p.m. Linear term 1st order parameter (mechanistic model)	5	2.8	3.413	D5Rat178
7	HR	g14	DELTA_HS_M_LS_HR	heart rate, high salt minus low salt, basal state - lights on and rat asleep	5	2.8	3.006	D5Rat178
8	LIPIDS	g16	BW_TOTAL_CHOLESTEROL_VALUE	Plasma total cholesterol value, low salt diet following Lasix	5	2.8	3.065	D5Mgh25

BioInformatics Research Center Medical College of Wisconsin Email:zwang@mcw.edu Web:http://brc.mcw.edu/