Physiological Profiling
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LOD threshold (Thrd) for Parametric analysis is 2.8 or 2.5 (in a few specific cases). LOD threshold (Thrd) for Non_parametric analysis is 3.5. One phenotype can be mapped on different chromosomes. Group g1 through g18 and phen-group refer to ordering and grouping of phenotypes
No.	Phen. group	Phen. grp. #	Phen. name	Phen. Description	Chr#	Thrd	LOD Peak	Marker
1	RVR ANG	g1	TR_D_ANG2_M_CTRL_RVR_LN	Delta renal vascular resistance from AngII dose 2 minus control renal vascular resistance	6	2.8	3.224	D6Mit8
2	RVR NE	g2	TR_ARVA_NE_SLOPE_RVR_LN	Slope of the regression for each rat; log dose of NE vs the RVR corresponding to that dose for each of three doses	6	2.8	2.876	D6Mgh11
3	BP T-SERIES	g11	BPTSM_TPM_ALPHA3	Tuesday p.m. Linear term 2nd order parameter (mechanistic model)	6	3.5	3.66407	D6Rat163
4	BP DRUG	g12	DELTA_ACH3_M_LNAME_BP	Delta mean arterial pressure from acetylcholine dose 3 minus L-NAME mean arterial pressure	6	3.5	3.52475	D6Rat163
5	BP DRUG	g12	DELTA_ACH1_M_CTRL_BP	Delta mean arterial pressure from acetylcholine dose 1 minus pre-Ach control mean arterial pressure	6	2.8	3.291	D6Rat78

BioInformatics Research Center Medical College of Wisconsin Email:zwang@mcw.edu Web:http://brc.mcw.edu/