Physiological Profiling


	Physiological Profiling
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LOD threshold (Thrd) for Parametric analysis is 2.8 or 2.5 (in a few specific cases). LOD threshold (Thrd) for Non_parametric analysis is 3.5. One phenotype can be mapped on different chromosomes. Group g1 through g18 and phen-group refer to ordering and grouping of phenotypes
No.	Phen. group	Phen. grp. #	Phen. name	Phen. Description	Chr#	Thrd	LOD Peak	Marker
1	RVR ANG	g1	TR_D_ANG2_M_CTRL_RVR_LN	Delta renal vascular resistance from AngII dose 2 minus control renal vascular resistance	6	2.8	3.224	D6Mit8
2	RVR ANG	g1	TR_D_ANG3_M_CTRL_RVR_LN	Delta renal vascular resistance from AngII dose 3 minus control renal vascular resistance	5	2.5	2.798	D5Mgh8
3	RVR NE	g2	TR_ARVA_NE_SLOPE_RVR_LN	Slope of the regression for each rat; log dose of NE vs the RVR corresponding to that dose for each of three doses	6	2.8	2.876	D6Mgh11
4	RVR NE	g2	TR_D_NE1_M_CTRL_RVR_LN	Delta renal vascular resistance from Norepinephrine dose 1 minus control renal vascular resistance	10	2.8	3.873	D10Mgh11
5	RVR ACH	g3	DELTA_ACH2_M_CTRL_RVR	Delta renal vascular resistance from Acetylcholine dose 2 minus pre-Ach control renal vascular resistance	5	2.8	4.149	D5Mgh23
6	RVR ACH	g3	TR_D_ACH4_M_LNAME_RVR_LN	Delta renal vascular resistance from Acetylcholine dose 4 minus L-NAME renal vascular resistance	17	2.8	2.881	D17Rat59
7	RBF ANG	g4	DELTA_ANG2_M_CTRL_RBF	Delta renal blood flow from AngII dose 2 minus control renal blood flow	12	2.8	2.998	D12Mgh9
8	RBF ANG	g4	DELTA_ANG3_M_CTRL_RBFK	Delta renal blood flow per gram kidney weight from AngII dose 3 minus control renal blood flow per gram kidney weight	19	2.8	2.818	D19Mit10
9	RBF NE	g5	ARVA_LS_PRE_NE_RBF_MEAN	Control renal blood flow per gram kidney weight after AngII but before Norepi, anesthetized rat, mean of last two steady state minutes of control period	15	2.8	3.071	D15Mgh11
10	RBF ACH	g6	DELTA_ACH1_M_CTRL_RBF	Delta renal blood flow from Acetylcholine dose 1 minus pre-Ach control renal blood flow	5	3.5	4.16275	D5Mgh5
11	RBF ACH	g6	DELTA_ACH1_M_CTRL_RBFK	Delta renal blood flow per gram kidney weight from Acetylcholine dose 1 minus pre-Ach control renal blood flow per gram kidney weight	5	3.5	4.36965	D5Mgh5
12	RBF ACH	g6	DELTA_ACH2_M_CTRL_RBF	Delta renal blood flow from Acetylcholine dose 2 minus pre-Ach control renal blood flow	5	2.8	3.296	D5Mit4
13	RBF ACH	g6	DELTA_ACH4_M_LNAME_RBF	Delta renal blood flow from Acetylcholine dose 4 minus L-NAME renal blood flow	3	2.8	2.814	D3Rat116
14	RBF ACH	g6	DELTA_ACH4_M_LNAME_RBFK	Delta renal blood flow per gram kidney weight from Acetylcholine dose 4 minus L-NAME renal blood flow per gram kidney weight	3	2.8	2.895	D3Rat116
15	EXCR	g7	TR_RF_HS_URINE_VOL_SQT	24 hour urine volume in ml, rat on high salt diet	4	2.8	2.834	D4Mit27
	EXCR	g7	TR_RF_HS_URINE_VOL_SQT	24 hour urine volume in ml, rat on high salt diet	8	2.8	3.871	D8Mit16
16	EXCR	g7	RF_LS_URINE_NA	sodium concentration of urine, low salt diet following Lasix	1	2.8	4.643	D1Mgh3
17	EXCR	g7	TR_RF_LS_24HR_EXCR_K_LN	potassium excretion rate, low salt diet following Lasix	1	2.8	4.66	D1Mit10
18	EXCR	g7	TR_RF_LS_URINE_K_LN	potassium concentration of urine, low salt diet following Lasix	1	2.8	4.589	D1Mit10
	EXCR	g7	TR_RF_LS_URINE_K_LN	potassium concentration of urine, low salt diet following Lasix	3	2.8	3.708	D3Mgh6
	EXCR	g7	TR_RF_LS_URINE_K_LN	potassium concentration of urine, low salt diet following Lasix	4	2.8	2.988	D4Mit2
19	KID FUNC	g8	TR_RF_HS_24HR_EXCR_PROTEIN_LN	protein excretion rate, high salt diet	18	2.8	2.981	D18Mgh9
20	KID FUNC	g8	TR_RF_HS_EXCR_PROT_MG24HR_LN	protein excretion rate, high salt diet	18	2.8	2.933	D18Mgh7
21	KID FUNC	g8	TR_RF_HS_24HR_URINE_PROTEIN_LN	protein concentration of urine, high salt diet	8	2.8	2.924	D8Mit4
22	KID FUNC	g8	AP_RGHT_KIDNEY_WGHT	right kidney weight	7	2.8	3.934	D7Mit14
	KID FUNC	g8	AP_RGHT_KIDNEY_WGHT	right kidney weight	12	2.8	3.571	D12Mit7
23	KID FUNC	g8	AP_LFT_KIDNEY_WGHT	left kidney weight	7	3.5	4.62096	D7Mit14
24	BP	g9	RAWBP_DAY1_MAP	mean blood pressure, High salt, day 1, mean of 3 hour blood pressure recording	18	3.5	3.53873	D18Rat57
25	BP	g9	RAWBP_DAY2_DAP	Diastolic blood pressure, High salt, day 2, mean of 3 hour blood pressure recording	18	2.8	2.829	D18Rat57
26	BP	g9	RAWBP_DAY2_MAP	mean blood pressure, High salt, day 2, mean of 3 hour blood pressure recording	18	3.5	4.41065	D18Rat57
27	BP	g9	TR_BPX_HSACTIVEDIAMEAN_LN	Diastolic blood pressure, arterial catheter implanted, high salt diet, average of 3 hours collection time, active state - lights off and rat awake	18	2.5	2.791	D18Rat57
28	BP	g9	BPX_HSBASALMAPMEAN	Mean arterial blood pressure, arterial catheter implanted, high salt diet, mean of best 2 out of 3 days, 3 hours collection time per day, basal state - lights on and rat asleep,	18	3.5	3.88752	D18Rat57
29	BP	g9	BPX_HSACTIVEMAPMEAN	Mean arterial pressure, arterial catheter implanted, high salt diet, average of 3 hours collection time, active state - lights off and rat awake	18	3.5	4.36484	D18Rat57
30	BP	g9	DELTA_WAKE_M_DAY2AM_SYSBP	systolic blood pressure, high salt diet, p.m. active state value minus a.m. basal state (mean of 3 hours recording each)	2	3.5	3.66819	D2Mgh29
	BP	g9	DELTA_WAKE_M_DAY2AM_SYSBP	systolic blood pressure, high salt diet, p.m. active state value minus a.m. basal state (mean of 3 hours recording each)	15	3.5	3.53715	D15Mgh9
31	BP	g9	DELTA_HS_M_LS_MAPBP	mean arterial pressure, high salt minus low salt, basal state - lights on and rat asleep	18	3.5	4.61609	D18Rat57
32	BP	g9	DELTA_HS_M_LS_SYSBP	Systolic blood pressure, high salt minus low salt, basal state - lights on and rat asleep	8	2.8	3.398	D8Mit4
	BP	g9	DELTA_HS_M_LS_SYSBP	Systolic blood pressure, high salt minus low salt, basal state - lights on and rat asleep	18	2.8	3.643	D18Mit3
33	BP SD	g10	DELTA_HS_M_LS_MAPSD	mean arterial pressure standard deviation , high salt minus low salt, basal state - lights on and rat asleep	3	2.8	2.848	D3Mit4
	BP SD	g10	DELTA_HS_M_LS_MAPSD	mean arterial pressure standard deviation , high salt minus low salt, basal state - lights on and rat asleep	7	2.8	2.825	D7Rat135
34	BP SD	g10	TR_BPX_HSACTIVEMAPSD_LN	Mean arterial pressure standard deviation, arterial catheter implanted, high salt diet, average of 3 hours collection time, active state - lights off and rat awake	1	2.8	3.836	D1Mit2
35	BP SD	g10	TR_BPX_LSBASALDIASD_SQT	Diastolic blood pressure standard deviation, arterial catheter implanted, low salt diet following Lasix, 3 hours collection time one day, basal state - lights on and rat asleep,	13	2.8	2.98	D13Mgh18
36	BP SD	g10	TR_RAWBP_DAY3_DAPSD_LN	Diastolic blood pressure standard deviation, High salt, day 3, mean of 3 hour blood pressure recording	2	2.8	3.665	D2Mgh12
37	BP SD	g10	TR_RAWBP_DAY3_MAPSD_LN	mean blood pressure standard deviation, High salt, day 3, mean of 3 hour blood pressure recording	2	2.8	4.377	D2Mgh12
38	BP SD	g10	BPX_HSACTIVEDIASD	Diastolic blood pressure standard deviation, arterial catheter implanted, high salt diet, average of 3 hours collection time, active state - lights off and rat awake	1	3.5	3.60022	D1Mit3
39	BP SD	g10	BPX_HSBASALMAPSD	Mean arterial pressure standard deviation, arterial catheter implanted, high salt diet, mean of best 2 out of 3 days, 3 hours collection time per day, basal state - lights on and rat asleep,	2	3.5	3.61192	D2Mgh12
40	BP SD	g10	RAWBP_DAY2_DAPSD	Diastolic blood pressure standard deviation, High salt, day 2, mean of 3 hour blood pressure recording	18	3.5	3.59112	D18Rat57
41	BP SD	g10	RAWBP_DAY2_MAPSD	mean blood pressure standard deviation, High salt, day 2, mean of 3 hour blood pressure recording	18	3.5	3.97196	D18Rat57
42	BP SD	g10	RAWBP_DAY3_SAPSD	Systolic blood pressure standard deviation, High salt, day 3, mean of 3 hour blood pressure recording	1	3.5	3.71601	D1Mit2
43	BP T-SERIES	g11	BPTSM_TAM_ALPHA1	Tuesday a.m. Linear term 0th order parameter (mechanistic model)	7	2.8	4.043	D7Mit10
44	BP T-SERIES	g11	BPTSM_TPM_ALPHA1	Tuesday p.m. Linear term 0th order parameter (mechanistic model)	2	2.8	3.476	D2Mgh1
45	BP T-SERIES	g11	BPTSM_TPM_ALPHA2	Tuesday p.m. Linear term 1st order parameter (mechanistic model)	5	2.8	3.413	D5Rat178
	BP T-SERIES	g11	BPTSM_TPM_ALPHA2	Tuesday p.m. Linear term 1st order parameter (mechanistic model)	18	2.8	3.807	D18Mgh3
	BP T-SERIES	g11	BPTSM_TPM_ALPHA2	Tuesday p.m. Linear term 1st order parameter (mechanistic model)	18	2.8	3.201	D18Mgh9
46	BP T-SERIES	g11	BPTSM_WAM_ALPHA2	Wednesday a.m. Linear term 1st order parameter (mechanistic model)	18	2.8	3.022	D18Mgh7
47	BP T-SERIES	g11	BPTSM_WAM_XBAR	Wednesday a.m. Set point for baro-receptor response (mechanistic model)	18	2.8	3.053	D18Rat57
48	BP T-SERIES	g11	BPTSM_TAM_ADA	Tuesday a.m. Exponential scaling factor, baro-receptor response (mechanistic model)	13	3.5	3.72886	D13Mit4
49	BP T-SERIES	g11	BPTSM_TPM_ALPHA3	Tuesday p.m. Linear term 2nd order parameter (mechanistic model)	6	3.5	3.66407	D6Rat163
50	BP T-SERIES	g11	BPTSM_WAM_D	Wednesday a.m. fractal parameter (fARIMA model)	2	3.5	3.62454	D2Mgh26
51	BP T-SERIES	g11	TR_BPTSM_TAM_MEAN_LN	Tuesday a.m. mean blood pressure	18	2.8	3.269	D18Rat57
52	BP T-SERIES	g11	TR_BPTSM_TAM_SD_LN	Tuesday a.m. standard deviation of blood pressure	4	2.8	2.979	D4Mgh12
53	BP DRUG	g12	ARVA_LS_CNTRL_MAP_MEAN	Control mean arterial pressure, anesthetized rat, mean of last two steady state minutes of control period	12	2.8	2.973	D12Mgh5
54	BP DRUG	g12	ARVA_LS_PRE_NE_MAP_MEAN	Control mean arterial pressure after AngII but before Norepi, anesthetized rat, mean of last two steady state minutes of control period	1	2.8	3.127	D1Mit18
55	BP DRUG	g12	ARVA_LS_ACH_1_MAP_MEAN	Acetylcholine dose 1 (0.095 ug/kg/min), Mean arterial pressure, anesthetized rat, mean of last two steady state minutes of period	10	2.5	2.504	D10Mgh14
56	BP DRUG	g12	ARVA_LS_ACH_D2_MAP_MEAN	Acetylcholine dose 2 (0.19 ug/kg/min), Mean arterial pressure, anesthetized rat, mean of last two steady state minutes of period	10	2.5	2.792	D10Mgh23
57	BP DRUG	g12	ARVA_LS_ACH_D4_MAP_MEAN	Acetylcholine dose 4 (0.19 ug/kg/min), Mean arterial pressure, anesthetized rat, mean of last two steady state minutes of period	12	2.8	3.041	D12Mit7
58	BP DRUG	g12	DELTA_ANG1_M_CTRL_BP	Delta mean arterial pressure from AngII dose 1 minus control mean arterial pressure	7	2.8	2.851	D7Mit10
59	BP DRUG	g12	DELTA_ANG3_M_CTRL_BP	Delta mean arterial pressure from AngII dose 3 minus control mean arterial pressure	13	2.8	2.944	D13Mgh4
60	BP DRUG	g12	DELTA_NE3_M_CTRL_BP	Delta mean arterial pressure from Norepinephrine dose 3 minus control mean arterial pressure	3	2.8	3.129	D3Mgh18
61	BP DRUG	g12	DELTA_ACH3_M_LNAME_BP	Delta mean arterial pressure from acetylcholine dose 3 minus L-NAME mean arterial pressure	6	3.5	3.52475	D6Rat163
62	BP DRUG	g12	TR_D_LNAME_M_ACH2_BP_LN	Delta mean arterial pressure from L-NAME minus Acetylcholine dose 2 mean arterial pressure	2	2.8	3.035	D2Mgh15
63	BP DRUG	g12	DELTA_ACH1_M_CTRL_BP	Delta mean arterial pressure from acetylcholine dose 1 minus pre-Ach control mean arterial pressure	6	2.8	3.291	D6Rat78
64	NEUROENDOCRINE	g13	BW_LS_PLASMA_RENIN	Plasma renin, low salt diet following Lasix	1	2.8	4.467	D1Mit10
	NEUROENDOCRINE	g13	BW_LS_PLASMA_RENIN	Plasma renin, low salt diet following Lasix	4	2.8	2.822	D4Mgh7
65	NEUROENDOCRINE	g13	TR_BW_RENIN_LS_MINUS_HS_SQT	Change in plasma renin; low salt minus high salt value	4	2.8	3.045	D4Mgh7
66	HR	g14	RAWBP_DAY1_HRTRT	heart rate, High salt, day 1, mean of 3 hour blood pressure recording	2	2.8	3.165	D2Rat64
	HR	g14	RAWBP_DAY1_HRTRT	heart rate, High salt, day 1, mean of 3 hour blood pressure recording	20	2.8	3.163	RS19b
67	HR	g14	DELTA_HS_M_LS_HR	heart rate, high salt minus low salt, basal state - lights on and rat asleep	5	2.8	3.006	D5Rat178
68	HR	g14	DELTA_WAKE_M_DAY2AM_HR	heart rate, high salt diet, p.m. active state value minus a.m. basal state (mean of 3 hours recording each)	1	2.8	2.973	D1Mgh7
69	HR SD	g15	TR_RAWBP_DAY1_HRTRTSD_LN	heart rate standard deviation, High salt, day 1, mean of 3 hour blood pressure recording	2	2.8	3.373	D2Mit15
70	HR SD	g15	RAWBP_DAY2_HRTRTSD	heart rate standard deviation, High salt, day 2, mean of 3 hour blood pressure recording	12	3.5	3.56232	D12Rat43
71	HR SD	g15	RAWBP_DAY3_HRTRTSD	heart rate standard deviation, High salt, day 3, mean of 3 hour blood pressure recording	4	3.5	3.54628	D4Mit1
72	HR SD	g15	TR_D_WAKE_M_DAY2AM_HRSD_LN	heart rate standard deviation, high salt diet, p.m. active state value minus a.m. basal state (mean of 3 hours recording each)	17	2.8	4.094	D17Rat9
73	LIPIDS	g16	BW_HDL_VALUE	Plasma HDL value, low salt diet following Lasix	18	2.8	3.826	D18Mit8
	LIPIDS	g16	BW_HDL_VALUE	Plasma HDL value, low salt diet following Lasix	18	2.8	3.995	D18Mgh7
74	LIPIDS	g16	BW_TOTAL_CHOLESTEROL_VALUE	Plasma total cholesterol value, low salt diet following Lasix	1	2.8	3.013	D1Mgh7
	LIPIDS	g16	BW_TOTAL_CHOLESTEROL_VALUE	Plasma total cholesterol value, low salt diet following Lasix	5	2.8	3.065	D5Mgh25
75	MORPHO	g17	RF_DELTA_WGHT	Change in body weight between day of catheter surgery and day of Lasix injection	7	2.8	3.348	D7Rat135
76	MORPHO	g17	RF_WGHT	Body weight of rat prior to Lasix injection	14	2.8	3.028	D14Mit7
77	MORPHO	g17	TR_AP_LFT_VENTRICLE_WGHT_LN	left ventricle weight in grams	14	2.8	2.971	D14Mit7
78	MORPHO	g17	AP_HEART_WGHT	heart weight in grams	2	3.5	3.50746	D2Mgh12
	MORPHO	g17	AP_HEART_WGHT	heart weight in grams	8	3.5	3.77443	D8Mit13
	MORPHO	g17	AP_HEART_WGHT	heart weight in grams	10	3.5	3.84606	D10Mgh23
79	MORPHO	g17	ARVA_WGHTCS	Body weight prior to anesthesia for acute protocol	3	2.8	3.503	D3Mgh6
	MORPHO	g17	ARVA_WGHTCS	Body weight prior to anesthesia for acute protocol	18	2.8	2.963	D18Mit8
80	MISC	g18	AP_AORTA_LESION_NUMBER	number of aortic lesions found in specimen analyzed	11	3.5	3.64538	D11Mgh3
81	MISC	g18	TR_BW_WBC_LN	White blood cell count	12	2.8	3.162	D12Mgh5